Forward Pharma is a privately held biotechnology company, founded in 2005 in Copenhagen, Denmark. The company is focused on the immunomodulatory compound dimethyl fumarate for the treatment of immune diseases.
FP187 (dimethyl fumarate) is Forward Pharma’s oral fumaric acid ester (FAE) clinical product candidate Read more for treatment of possible immune disorders including multiple sclerosis Read more and psoriasis Read more.
FP187 Development Chart. Enlarge
Science of dimethyl fumarate
In the coming year we should abandon interferons and glatiramer acetate as first-line therapy for MS: yes. Fox RJ, Mult Scler. 2013. Link
Multiple sclerosis in 2012: Novel therapeutic options and drug targets in MS. Methner A., Zipp F., Nature Reviews Neurology 2013. Link
Dimethyl Fumarate Modulation of Immune and Antioxidant Responses: Application to HIV Therapy. Gill AJ and Kolson DL, Crit Rev Immunol. 2013. Link
Dimethyl fumarate – only an anti-psoriatic medication? Meissner M et al., JDDG 2012. Link
Dimethyl Fumarate Inhibits Dendritic Cell Maturation via NF-kB and ERK1/2 and MSK1 Signaling. Peng H et al., JBC 2012. Link